Regarding the quants at Renaissance Technologies:
I can only look at them and realize that you have the gods of the business and then you have mere mortals like me, Wadhwani said, echoing the view of the entire industry. Excerpt from Mallaby, "More Money Than God," pp. 298, 2010.
March 2008, Jim Simons interviewed by Bill Zimmerman on mathematics.
December 2010 at MIT about his remarkable careers. Credit to Infectious Greed for pointing me to the second video.